Can 17 years of diabetes cause kidney damage in a woman?

Question

Hello doctor,

My mother has had diabetes for 17 years. It is the first time in years of laboratory tests that she tested positive for protein in urine, but with a normal creatinine (though it is close to the last range of normal). Does this mean her kidney starts failing? She is also complaining about difficulty in urinating. I cannot provide her medications because I do not recall the names of her medications, but I know she is injecting Insulin and has other medications for blood pressure, heart disease, and diabetes besides Insulin.

Kindly help.

Thank you in advance.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

It is completely understandable to feel concerned that you are looking out for your mom, and that is important. The presence of protein in the urine (+ protein) for someone with a long history of diabetes (17 years) can be an early sign of diabetic kidney involvement, also known as diabetic nephropathy. However, the fact that her creatinine is still within the normal range is somewhat reassuring, even if it is at the higher end.

Here is what this likely means: The kidneys may be starting to show early signs of stress, but not yet in failure. Protein in the urine can appear before creatinine levels rise, so this might be an early warning sign — not kidney failure, but a sign to take action.

Her complaint of difficulty urinating may or may not be related. It could also point to a urinary tract infection (UTI) or bladder issues, especially if she has had diabetes for many years, as nerves controlling the bladder can also be affected (called diabetic cystopathy).

What is important to do next:

Follow up with a doctor, ideally a nephrologist or endocrinologist. Ask about a urine albumin-to-creatinine ratio (ACR) test. It is more specific and sensitive for detecting kidney problems early. Monitor blood pressure (BP), as high BP can worsen kidney function. Manage blood sugar levels strictly, as this helps slow any kidney damage. Drink enough water unless a doctor says otherwise, especially if you have difficulty urinating.

You are doing the right thing by catching this early. With the right steps, kidney damage can often be slowed or even stabilized, so it is not too late.

I hope this helps you.

Thank you.