Will stem cell therapy for multiple sclerosis affect fertility?

Question

Hello doctor,

My younger sister, who is 26, has aggressive multiple sclerosis and has had three relapses in the past year despite being on disease-modifying therapy. She is physically active and wants to avoid further disability.

Our neurologist briefly mentioned that autologous hematopoietic stem cell transplant (AHSCT) is being used in some patients with multiple sclerosis (MS). But, our concerns are:

Is this actually an FDA-approved option or still considered experimental?
What are the risks for a young woman, especially if she might want kids in the future?
And how do we differentiate between real centers and clinics just pushing risky stem cell treatments?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Autologous hematopoietic stem cell transplant (AHSCT) for multiple sclerosis (MS) is not yet approved by the FDA (Food and Drug Administration) for MS. AHSCT is sometimes utilized off-label for severe cases of the disease.

It may be considered a viable option for patients with highly active MS that does not respond to other therapies, but it remains experimental and is not widely accessible.

The procedure involves chemotherapy and stem cell infusion, which carries risks such as infection, infertility, and potential organ complications.
There may be implications for future fertility, particularly for those wishing to have children in the future. Discussing the possibility of freezing eggs or embryos before treatment could be beneficial for you.
You need to choose a reputable stem cell center that adheres to FDA guidelines and has published research. Exercise caution with clinics that promote unverified or costly treatments without a proven history.

I hope this information helps you.

Feel free to ask further queries.

Thank you.