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Benzoyl Peroxide in Acne Prevention - Side Effects and Benefits

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Benzoyl peroxide is an acne treatment medication. It is available in various formulations, such as creams, lotions, gels, and soaps.

Written by

Dr. Sameeha M S

Medically reviewed by

Dr. Dhepe Snehal Madhav

Published At April 23, 2024
Reviewed AtApril 23, 2024

Introduction

The antibacterial properties of benzoyl peroxide make it a potential topical treatment for acne. It is available with a prescription, over the counter, as part of daily cleansers, and other skincare products. Many skin care products contain benzoyl peroxide, including face cleansers, gels, and lotions. This article discusses the applications of benzoyl peroxide and its possible adverse effects.

What Is Benzoyl Peroxide?

Acne outbreaks are treated with benzoyl peroxide. It comes in various forms, including cleansers, toner-like solutions, lotions, creams, and gels. Benzoyl peroxide is a bactericidal agent (which means it kills bacteria). Propionibacterium acnes are the microorganisms responsible for acne, which are killed by benzoyl peroxide when applied topically. Benzoyl peroxide does not cause antibiotic resistance, in contrast to topical antibiotic therapies for acne, like Clindamycin.

How Does Benzoyl Peroxide Work?

  • Topical benzoyl peroxide has bactericidal properties against Cutibacterium acnes, a major cause of acne vulgaris. After being absorbed by the skin, benzoyl peroxide transforms into benzoic acid.

  • The renal system excretes approximately five percent of the benzoic acid absorbed systemically. Cysteine metabolizes the remaining benzoic acid in the skin, creating active free-radical oxygen species that cause bacterial proteins to oxidize.

  • The quantity of P. acnes in hair follicles was reduced by 98 percent, and free fatty acids decreased by 50 percent following a two-week application of ten percent benzoyl peroxide daily. These findings are identical to those seen following four weeks of antibiotic therapy.

  • In addition to its keratolytic action, topical benzoyl peroxide has modest sebostatic (reduce sebum) properties that enhance its effectiveness in treating comedonal acne. Benzoyl peroxide stimulates the growth of epithelium quickly and the healthy formation of granulation tissue, which effectively cures cutaneous ulcers.

  • Moreover, benzoyl peroxide unclogs pores by eliminating dead skin cells and excess oil, which stops the accumulation of debris that causes blackheads and whiteheads. With time, the skin will become clearer and smoother because of the exfoliating qualities of this product.

How to Use Benzoyl Peroxide for Acne?

The method for using benzoyl peroxide varies depending on the product. It is important to adhere to the instructions on the product label and refrain from using it more frequently than suggested. Benzoyl peroxide should not be used in the mouth, nose, or close to the eyes. Try to use only one benzoyl peroxide product at a time to prevent adverse effects.

1. Benzoyl Peroxide Face Wash: Soaps, foamy face washes, and cleansers are commonly used one to three times per day. If the skin is sensitive, use benzoyl peroxide face wash daily.

  • Wet the skin with warm water first.

  • Make a lather with the soap on the face.

  • Thoroughly rinse with warm water.

  • With a cloth, pat dry the face.

2. Benzoyl Peroxide Toners: After cleansing and drying the skin, apply toner. These products are available as medicated pads or liquids.

  • Use a wet pad or a cotton ball to apply the liquid.

  • Apply the drug to the acne areas.

  • One can also lightly wipe the pad across the skin without rubbing.

  • Before applying any more products or makeup, let the area air dry.

  • Applying toner to difficult areas or throughout the face is one advantage over using a face wash.

3. Leave-on Treatments: Gels and creams containing benzoyl peroxide are often more effective. These can be used all over or just on particular acne.

  • Apply a thin coating of cream or gel to the region of the skin that needs treatment after washing and drying it.

  • Allow it to be there for a few minutes.

  • After half an hour, if the medication is still noticeable, one can use a moist cloth to remove any leftovers carefully.

  • Before going outdoors in the sun, apply sunscreen.

  • One can apply leave-on-spot treatments one to three times a day.

4. Benzoyl Peroxide Masks: Unless specifically directed by a specialist, benzoyl peroxide acne masks should not be applied more than once a week.

  • First, use a non-medicated cleanser to wash the face, and then pat dry.

  • Evenly cover the desired treatment area with the mask.

  • Follow the guidelines on the package or leave the treatment on for 15 to 20 minutes.

  • Use warm water to rinse off.

What Are the Side Effects Associated With Benzoyl Peroxide?

Benzoyl peroxide's bleaching properties are the most common side effect, resulting in bleaching hair and discoloration of colored textiles—topical benzoyl peroxide at greater doses results in moderate erythema, scaling, and skin dryness. Additionally, a tiny fraction of individuals have case reports of contact dermatitis, which should raise suspicions in patients who experience significant erythema and irritation at the treatment site. Stopping benzoyl peroxide use is the wise course of action in such situations. Benzoyl peroxide may make the face more sensitive to the sun. It is suggested that sunscreen be applied every day.

What Are the Contraindications for Using Benzoyl Peroxide?

Patients with a history of known benzoyl peroxide hypersensitivity should not use benzoyl peroxide products. Benzoyl peroxide users who are allergic to cinnamon or other benzoic acid derivatives should use caution because cross-reactivity can happen. As benzoyl peroxide can cause significant irritation, it should not be used near the mouth, nose, eyes, mucous membranes, or open skin. If there has been contact with mucous membranes or eyes, ensure the affected regions are well-rinsed with water for at least fifteen minutes. Patients can reduce their risk of phototoxicity and skin irritation by wearing sunscreen and limiting their UV exposure.

Conclusion

Benzoyl peroxide's strong antibacterial and exfoliating qualities make it an essential part of acne treatment. Individuals should carefully follow the directions and consult a dermatologist regarding possible side effects before using benzoyl peroxide. Benzoyl peroxide can help prevent acne, lessen inflammation, and encourage healthier, clearer skin when used properly and as part of a thorough skincare regimen. Consult a dermatologist to determine the best way to use benzoyl peroxide in the skincare routine and to address any issues or queries.

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Dr. Dhepe Snehal Madhav
Dr. Dhepe Snehal Madhav

Venereology

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